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    Major, Zoltán, Zsigmond, MD

    To make an appointment or for more information, call +36 1 489 5200, where we will receive your call every weekday between 8.00 and 20.00.

    Professional experience

    • MEDFUTURE Research Center, Iuliu Ha?ieganu University of Medicine and Pharmacy, Research doctor
    • Department of Neurology, Clinic of Cluj-Napoca, Head of Department
    • National Center for Spinal Disorders
    • 2018 – : Buda Health Center

    Education and qualifications

    • 2004: Faculty of Medicine – Iuliu Ha?ieganu University of Medicine and Pharmacy
    • 2005: Clinical Pharmacology MSc, Iuliu Ha?ieganu University of Medicine and Pharmacy
    • 2010: Ph.D., Iuliu Ha?ieganu University of Medicine and Pharmacy
    • 2012: qualifying exam in neurology
    • 2015: Postdoctoral Course, Iuliu Ha?ieganu University of Medicine and Pharmacy
    • Electroencephalography
    • Electromyography

    Language of consultation

    • Hungarian
    • English
    • Romanian

    Professional and society membership

    • Hungarian Clinical Neurophysiology Society
    • Hungarian Epilepsy League

    Scientific activity

    • Number of articles: 4
    • Number of book chapters: 1
    • Number of specialist presentations: 18
    • Number of scientific projects: 8
    • Foreign or courses in Romania by foreign institutions

      22.04.-23.04.2008. - Meet the professor - Intensive epileptology training – workshop Zentrum Epilepsie Erlangen (ZEE), Erlangen, Germany

      19.07. – 27.07.2008. - 7th Summer School of Myology – Institut de Miologie Hospital Pitie-Salpetriere, Paris, France

      31.05.-04.06.2010. – PRIME Course Teaching and Learning, a course for medical educators – University of Brighton, Cluj-Napoca, Romania

      16.09.2010. – The multidisciplinary approach to NMDs: towards a harmonised practice – TREAT-NMD training, Milan, Italy

      28.06. – 29.06.2011. – LabAuthor Software training: LabAuthor Level I – Editing LabTutor Experiments, LabAuthor Level II – Creating New LabTutor Experiments – Oxford, UK

      02.09.-06.11.2014. – Writing in the Sciences – Stanford University - on-line course

      23.02.-27.02.2015. – Intraoperative neurophysiological monitoring training - National Center for Spinal Disorders, Budapest, Hungary

      12.11.-13.11.2015. – Intraoperative neurophysiological monitoring training - National Center for Spinal Disorders, Budapest, Hungary

      08.02.-12.02.2016 – Long-term epilepsy monitoring and intraoperative neurophysiological monitoring (ECoG) - National Institute for Clinical Neurosciences, Budapest, Hungary

      28.11.-06.12.2016 – Long-term EEG monitoring, including invasive EEG methods and ECoG – strip electrodes, sEEG, and intraoperative monitoring – National Institute for Clinical Neurosciences, Budapest, Hungary

      07.12.-09.12.2016 – Intraoperative neurophysiological monitoring training – National Center for Spinal Disorders, Budapest, Hungary

      22.02.-24.02.2017 – NIM Eclipse Neurophys Training – Neuromonitoring in Spine, Cranial & Cardiovascular Surgeries – Tolochenaz, Switzerland

      27.03.-31.03.2017 – Long-term EEG monitoring, including invasive EEG methods and ECoG – strip electrodes, sEEG, and intraoperative monitoring – National Institute for Clinical Neurosciences, Budapest, Hungary

      28.09.2017. – International workshop on New Trends in Rehabilitation Robotics, Cluj-Napoca, Romania

      27.11.-01.12.2017. – Intraoperative monitoring and epilepsy monitoring – observational training – Hopitaux Universitaires Geneve, Geneva, Switzerland

      08.12.2017. – Exchange programme: Introduction to LCIG therapy – Neurology Department, Semmelweis University, Budapest, Hungary
       
    • Courses at domestic (Romanian) institutions’ 

      13.03.-17.03.2006 – Electroneurografie si electromiografie – UMF „Iuliu Hatieganu”, Cluj-Napoca, Romania

      19.09.2007. – Educational Course: Focal Epilepsies in Childhood – EUREPA – European Epilepsy Academy, Sinaia, Romania

      22.10.-27.10.2007. – EMG, EEG si polisomnografie - UMF „Iuliu Hatieganu”, Cluj-Napoca, Romania

      24.05.-25.04.2008 – Baze in EMG si Neurografie – UMF „Carol Davila”/Akademiska Sjukhuset (Uppsala), Bucuresti, Romania

      14.05.-16.05.2009 – Traditie si progres in Farmacologie, Toxicologie si Oncologie clinica. Farmacologie, Algeziologie. Algeziologie pentru studenti si tineri medici – UMF „Gr.T. Popa”, Iasi, Romania

      13.05.-15.05.2010. – Durerea la copil si adolescent. Farmacologie, Algeziologie. Algeziologie pentru studenti si tineri medici – UMF „Gr.T. Popa”, Iasi, Romania

      18.03.2011. – Standards of care in the management of people with DMD – TREAT-NMD training, Bucuresti, Romania

      30.03.2012. – Initiere si diagnostic electroencefalografic – UMF „Carol Davila”, Bucuresti, Romania (durata 3 saptamani)

      30.11.2012. – Initiere si diagnostic electromiografic si neurografic - UMF „Carol Davila”, Bucuresti, Romania (durata 2 saptamani)

      01.03.2013. – Diagnosticul electromiografic si electroneurografic al afectiunilor neurologice si neurochirurgicale - UMF „Carol Davila”, Bucuresti, Romania (durata 2 saptamani)

      18.04.-20.04.2013. – Managementul Calitaii in Sectorul Medical si Comunicare Institutionala – Colegiul Medicilor Satu-Mare/CREST – Baile 1 Mai, Romania

      19.02.2015. – Seminariile Departamentului de Neurostiinte – Cluj-Napoca, Romania

      01.06.-04.06.2015. – RoNeuro Brain Days – Cluj-Napoca, Romania

      26.05.-27.05.2017. – Management of advanced Parkinson’s Disease with Infusion Therapies course - Bucuresti, Romania

      22.05.2017. - Workshop: Current and future applications of non-invasive and invasive BCIs - Cluj-Napoca, Romania
       

    Publications

    • Original full-text research articles published in Thomson-Reuters Web of Science (ISI) indexed journals:

    Meszaros I, Krausz TL, Fischer FE, Major ZZ, Popescu O. “Expression of immunomodulatory genes in inflammatory and autoimmune diseases.” Romanian Biotechnological Letters. 2010;6:5729-37

    Major ZZ. “Combined Evoked potentials in co-occuring ADHD and Epilepsy”. Ideggyogy Sz. 2011;64(7–8):248–56

    Krausz LT, Fischer-Fodor E, Major ZZ, Fetica B. “GITR-expressing regulatory T-cell subsets are increased in tumor-positive lymph nodes from advanced breast cancer patients as compared to tumor-negative lymph nodes”. Int J Immunopathol Pharmacol. 2012;25(1):59-66.

    Axente DD, Silaghi H, Silaghi CA, Major ZZ, Micu CM, Constantea NA.”Operative outcomes of robot-assisted transaxillary thyroid surgery for benign thyroid disease: early experience in 50 patients.” Langenbecks Arch Surg. 2013 Aug;398(6):887-94.

    Axente DD, Major ZZ, Micu CM, Constantea NA. “Technical Particularities of the Robot-Assisted Trans-Axillary Thyroidectomy.” Chirurgia. 2013;108(3):422-28

    Major ZZ, Văcăraş V, Buzoianu AD, Mureşanu FD. “Glatiramer Acetate Treatment-Related Effects on Visual EPs and P300 Wave in Patients Suffering from Multiple Sclerosis.” Neurophysiology. 2013;45(3):234-242.

    Krausz LT, Major ZZ, Muresanu DF, Chelaru E, Nocentini G, Riccardi C. “Characterization of CD4+ and CD8+ Tregs in a Hodgkin’s lymphoma patient presenting with myasthenia-like symptoms.” Ideggyogy Sz 2013;66(9–10):343–348.

    Văcăraş V, Major ZZ, Muresanu DF, Krausz LT, Marginean I, Buzoianu AD. “Effect of glatiramer acetate on peripheral blood BDNF and phosphorylated TrkB levels in relapsing-remitting multiple sclerosis”. CNS & Neurological Disorders – Drug Targets. 06/2014; 13(4):647-651. DOI: 10.2174/1871527313666140618110049

    Văcăra? V, Major ZZ, Mari? E, Major KA, Buzoianu AD. [Multiple sclerosis with stroke-like symptoms: a diagnostic challenge. Case report]. Orv Hetil 2015;156(37):1514–1518.

    Major ZZ, Vacaras V, Maris E, Crisan I, Florea B, Major KA, Muresanu DF. “The electrophysiological changes after 1Hz rTMS in ALS patients. A pilot study.” Ideggyogy Sz 2016;69(3–4):E026–E031.

    Vacaras V, Vithoulkas G, Buzoianu AD, Marginean I, Major ZZ, Vacaras V, Nicoara RD, Oberbaum M. “Homeopathic Treatment for Postpartum Depression: A Case Report.” Journal of Evidence-Based Complementary & Alternative Medicine 2016;(2016):1-4

    Vacaras V, Major ZZ, Buzoianu AD. “Brain-derived neurotrophic factor levels under chronic natalizumab treatment in multiple sclerosis. A preliminary report.” Neurol Neurochir Pol 2017, (51):221-226.

    Axente DD, Major ZZ, Dudric VN, Constantea NA. “Control of the functionality of the brachial plexus during robot-assisted transaxillary thyroid surgery.” Neurophysiology 2017; 49(4): 295-300.

    • Meeting abstracts published in Thomson-Reuters Web of Science (ISI) indexed journals:

    Buzoianu AD, Bocsan IC, Militaru FC, Major ZZ. “The effects of topiramate on acute anxiety models in rats.” Eur Neuropsychopharm. 2008;18(Suppl 4):S502-503

    Bocsan IC, Buzoianu AD, Militaru FC, Major ZZ. “The influence of lamotrigine on rat behaviour. “Basic Clin Pharmacol. 2009;105:148

    Buzoianu AD, Bocsan IC, Maier C, Trifa A, Militaru FC, Perju-Dumbrava L, Major ZZ. “Genotype–phenotype correlations between the CYPC19 polymorphism and pharmacokinetic parameters in Romanian epileptic patients.” Eur Neuropsychopharm. 2011;21(Suppl 3):S284

    Bocsan IC, Buzoianu AD, Major ZZ, Maier C, Trifa AP, Popp RA, Militaru FC, Perju-Dumbrava L, Popescu C. “The MDR1 C3435T polymorphism and valproic acid plasmatic level in Romanian epileptic patients.” Eur Neuropsychopharm. 2011;21(Suppl 3):S287
     

    • Proceedings papers published in Thomson-Reuters Web of Science (ISI) indexed journals:

    Bocsan IC, Buzoianu AD, Militaru FC, Major ZZ. The influence of lamotrigine on rat behaviour. Reprinted from 9th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT) International Proceedings. Medimond
     

    • Original full-text research articles published in journals indexed in international databases (non-ISI):

    Şandor Vl, Volda M, Bocşan CI, Şandor CT, Meszaros I, Major ZZ, Krausz LT. “Comparative effects of keto-phenylbutazone and streptokinase on UV-induced skin inflammation in guinea pigs.” Timişoara Medical Journal 2006;56(2):280-283.

    Major ZZ, Benga I. “Treatment options in ADHD.” Clujul Medical. 2009;82(4):484-487.

    Major ZZ, “Benga I. Stimulus related potentials in ADHD-epilepsy comorbidity in children. Preliminary report.” Clujul Medical. 2010;83(2):313-317.

    Bocsan C, Major ZZ, Maier C, Popp R, Iuga C, Trifa A, Militaru FC, Buzoianu AD. “Study of the phenotypic variation expression in the metabolizing status of Romanian epileptic patients.” Therapeutics Pharmacology and Clinical Toxicology. 2010;3:224-28.

    Major ZZ, Buzoianu AD, Perju-Dumbrava L, Marginean I, Bocsan IC, Major KA. QEEG: “Relative power findings in epilepsy.” Therapeutics Pharmacology and Clinical Toxicology. 2010;4:269-73.

    Major ZZ, Buzoianu AD, Perju-Dumbravă L, Mărginean I, Krausz LT, Văcăraş V et al. “The effect of epilepsy on the age-related prolongation of the P300.” Fiziologia/Physiology. 2010;20(4):24-7.

    Buzoianu AD, Bocşan IC, Maier C, Trifa AP, Popp RA, Perju Dumbrava L, Sabin O, Militaru C, Brusturean E, Major ZZ, Popescu O. “Genotype-phenotype correlations between the alleles of the MDR1 C3435T polymorphism and pharmacokinetic parameters in Romanian epileptic patients.” Therapeutics Pharmacology and Clinical Toxicology. 2011;1:40-44.

    Vacaras V, Major ZZ, Buzoianu AD. “Disease modifying pharmacological approach of multiple sclerosis. A focus on Glatiramer acetate.” Therapeutics Pharmacology and Clinical Toxicology. 2011;15(4):265-69.

    Văcăraş V, Major ZZ, Buzoianu AD. “One year on glatiramer acetate. Preliminary report on disease activity and disability evolution.” HVM Bioflux. 2012;4(3):107-109.

    Văcăraş V, Major ZZ, Seewooram R, Major KA, Muresanu DF, Buzoianu AD. “Disease activity and disability evolution under glatiramer acetate: A clinical approach.” Neuropsychopharmacol Hung. 2014 Mar;16(1):11-8.

    Văcăra? V, Major ZZ, Mari? E, Major KA, Buzoianu AD. “A stepwise approach to adult onset leukodystrophy.” HVM Bioflux 2015;7(3):191-196.

    Major ZZ, Văcăra? V, Major KA, Mari? E, Mure?anu DF. “Wilson’s disease – a six year long journey to a positive diagnosis.” HVM Bioflux 2015;7(3):225-228.

    Major KA, Major ZZ, Carbone G, Pîslă A, Vaida C, Gherman B, Pîslă DL. “Ranges of motion as basis for robot-assisted post-stroke rehabilitation.” HVM Bioflux 2016;8(4):192-196.

    Vaida C, Carbone G, Major KA, Major ZZ, Plitea N, Pisla D. “On human robot interaction modalities in the upper limb rehabilitation after stroke.” Acta Technica Napocensis Series: Applied mathematics, Mechanics and Engineering, 2017;60(1):91-102.

    Major KA, Carbone G, Major ZZ, Vaida C, Pisla D. “Predefined assessment tools in robot assisted physical therapy after stroke.” Bulletin of theTransilvania University of Braşov, 2017;10(59)1:1-6.
     

    • Meeting abstracts published in journals indexed in international databases (non-ISI):

    Tomescu-Baciu A, Krausz LT, Major ZZ. “Immune receptor and cytokine expression in PMBC of Multiple Sclerosis patients.” Romanian Journal of Biochemistry. 2009;46(Supplementa):69.

    Banias-Palaghita L, Major ZZ, Catana C, Krausz TL, Vl Sandor. “Terapia cu fumaraţi în scleroza multiplă.” Medicina moderna. 2009;16(Suppl1):65-67.

    Şandor Vl, Danciu MM, Major ZZ, Gheban D, Sabin O, Butură A, Trîmbiţaş S. “Histo-chemical changes produced by reserpine and dopamine in the adrenal medulla.” Therapeutics Pharmacology and Clinical Toxicology. 2010;14(Supplement 3):37.

    Şandor Vl, Niculae CE, Pătrulescu AM, Magyar DS, Major ZZ. “The effects of fenoldopam in immobilization-induced gastric ulcers.” Therapeutics Pharmacology and clinical Toxicology. 2010;14(Supplement 3):39.

    Major ZZ, Alda G. “Neuromyelitis optica. Case report.” Clujul Medical 2013;86(Supplement 3):S207
     

    • Proceedings papers published in national journals (non-ISI):

    Sandor Vl, Amza LC, Kenez EA, Major ZZ, Magyar DS, Chirica M et al. Efectul amfetaminei in administrare acuta in convulsiile prin pentetrazol. Pain and Drug Research – Zilele Medicamentului Editia a XIX-a. 2010;(Proceeding):29-34. ISSN: 1843-1038

    Sandor Vl, Scurtea DM, Andresan-Marele FC, Gosa D, Butura A, Major ZZ, Kenez EA. Influenta tolperisonei asupra efectelor stricninei la broasca si soarece. Pain and Drug Research – Zilele Medicamentului Editia a XIX-a. 2010;(Proceeding):35-40. ISSN: 1843-1038
     

    • Book chapters

    Buzoianu AD, Militaru CF, Bocşan CI, Zoltan MZ. “Antidepressants in the treatment of pain.” In: Neurosciences: clinical application of recent knowledge (Eds. Dumitraşcu DL, Hoţoleanu C). Ed. Medicală Universitară “Iuliu Haţieganu”, Cluj-Napoca. 2008; 148-157. ISBN 978-973-693-289-2

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